This paper investigates the effect of utilizing cow bone powder, as a partial substitute of Portland cement, on mechanical properties and durability of cement mortar. Assessing 11th and 28th days’ compressive strength, water absorption, electrical resistance, and the elastic modulus in various percentages of replacement of bone powder, advises that adding this material up to 5% percent improves the aforementioned properties of cement mortar. According to studies and experiments, it seems that adding bone powder with the weight of 10% of cement materials, does not change the compressive strength of cement mortar, and It is even possible to achieve a compressive strength greater than 25 MPa by replacing more powder. All mixes of cement mortars is made of the same proportions of sand to cement and water to cement ratios, and the only variable mix ingredients is the different amounts of bone powder which is replaced with cement. Weight loss is another parameter which is studied in this work, when mix design are placed in sulfuric acid environment