The present study is focused on the effect of Soil–Structure Interaction (SSI) on the response of base-isolated buildings subjected to near-fault ground motions, where the vertical component of earthquake is not negligible. Seismic isolation can significantly mitigate the responses of building by the means of flexibility at the base and preventing resonance with the predominant frequencies of common earthquake. Nonetheless many of studies lack in the consideration of soft soil SSI near-fault effect besides vertical component to the isolated buildings. To this aim, a numerical investigation is carried out with reference to a two-dimensional lead rubber bearing (LRB) base-isolated five-story building, designed according to International Building Code (IBC) provisions. Four states of the base-isolated building have been analyzed non-linearly: (i) While it is subjected to a very dens soil (Vs>375 m/s), (ii) or a soft soil (Vs<200 m/s), (iii & iv) Each of mentioned situations with/without SSI effect. The subsoil is replaced by elastic spring and viscose dampers derived by National Earthquake Hazards Reduction Program (NEHRP) relations. The study contemplates non-negligible impression of soil-structure interaction of such special situation on the shear stresses and other factors of beams ruptures and columns failures over the soft-soil.