Nowadays, due to the lack of land in large cities and the increasing number of population, high-rise buildings are highlighted. In recent decades, structural systems used in high-rise buildings have included systems such as rigid frame, braced frame, shear walls, or a combination of these systems. But today, new systems such as tubular systems, truss belts and diagrids have both architecturally and structurally constructed in high-rise buildings. Considering that structures of this height require special considerations in design and implementation, this article explaines the fundamental challenges faced by structural engineers in designing high structures and provides suitable solutions for each one. The purpose of this major challenge in high-rise buildings compared to conventional buildings is to achieve a safe and efficient design with a view to an economic solution. Proposed solutions include reducing the amount of materials, reducing loads, observing sequence & schedules in construction, aerodynamic considerations and plan reforms.