There are numerous frame buildings with masonry infill walls throughout Iran. The seismic actions from earthquakes act on structures in various directions. However, in many cases, studying the effects of earthquakes are carried out by considering two perpendicular directions independently. This approach results in inaccurate estimation of the seismic response of masonry infill walls as the in-plane and out-of-plane responses of these walls simultaneously interact with each other and contribute to the response of the wall. In this study, the behavior of masonry infilled frames is numerically studied making use of finite element general-purpose software Abaqus. First, two representative infilled frames under in-plane and out-of-plane loading are calibrated. Them parametric study is performed in in-plane behavior of models with various vertical loads and lengths. Finally, the out-of-plane behavior of those models is evaluated under three different seismic demands. The results show, under certain in-plane displacements, the out-of-plane strength of the studied infill walls increases.