Practically there is a risk of explosion, and different structures' behavior should be examined against the effects of blast loadings. Sandwich panels are used for making some industrial and military structures. These panels are made of two sheets and an intermediate core. The core has a significant role in reducing the deflection and enhancing energy absorb of structure. In this article, sandwich panels' behavior, which are made of aluminum and steel, are examined against the blast loadings. In the process of analysis, two kind of profiles, which are: rectangular and elliptical, are considered as panel cores. The results show that all the panels that are completely made of aluminum have more damped energy than others. Those panels which have only aluminum sheets or aluminum cores are placed next to whole aluminum panels in order to damped energy level. Most of the deflections was belong to panel core with elliptical profile and the least deflection was for rectangular shaped profile.